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VERSION:2.0
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CALSCALE:GREGORIAN
X-WR-CALNAME:CoNDA Center Seminar with Dr. Helen Scharfman (NYU)
X-WR-TIMEZONE:Central Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260616T064103Z
UID:tag:localist.com\,2008:EventInstance_49606102145092
DTSTART:20250611T170000Z
DTEND:20250611T180000Z
DESCRIPTION:"Diverse roles of adult neurogenesis in epilepsy"\n\nCoNDA Cent
 er Seminar by Dr. Helen Scharfman\, PhD\n\nWednesday\, June 11th\, 2025\n\
 nVia Zoom |  Meeting ID: 926 9261 3428  |  Passcode: CONDA\n \n\nIn the ma
 mmalian brain\, the dentate gyrus (DG) generates new neurons and they norm
 ally become granule cells (GCs)\, the principal cell type. It has been sug
 gested that adult neurogenesis in the DG is required for normal cognitive 
 functions\, and it also has been suggested that adult neurogenesis plays a
  role in temporal lobe epilepsy (TLE)\, where seizures involve the DG. Our
  results indicate that newborn neurons influence activity in the DG normal
 ly by local network inhibition via the connections young neurons make with
  GABAergic interneurons. Our data also suggest\, remarkably\, that adult-b
 orn neurons reduce the effects of the convulsants kainic acid and pilocarp
 ine and reduce chronic seizures in a mouse model of TLE. However\, in the 
 epileptic adult neurogenesis increases greatly and many GCs are abnormal. 
 These aberrant adult-born GCs appear to facilitate seizures rather than in
 hibit them. We suggest that adult neurogenesis has diverse roles: in the n
 ormal brain\, adult-born neurons of the DG are promote cognitive functions
  and are protective\, whereas in TLE\, abnormalities that arise in adult-b
 orn neurons contribute to the pathophysiology of the disease\, and facilit
 ate seizures.\n\n\nHelen Scharfman received her BA in Biopsychology from V
 assar College in 1981 and her PhD in Pharmacology from the Uniformed Servi
 ces University in 1986. Her dissertation established the effects of GABA o
 n pyramidal cells and interneurons of rata visual cortical slices using si
 ngle cell electrophysiology. Her postdoctoral training was at the Universi
 ty of Washington in Seattle where she developed an interest in epilepsy in
  the Department of Neurological Surgery under the mentorship of Phillip Sc
 hwartzkroin. She then was a Research Associate at the Howard Huges Medical
  Institute under supervision of Paul Adams and S. Murray Sherman at the Un
 iversity of Stony Brook before being appointed as Assistant Professor at C
 olumbia University in the Departments of Pharmacology and Neurology. In 20
 07 she moved to the Nathan Kline Institute of Psychiatric Research and New
  York University Langone Health where she is currently Professor of Child 
 & Adolescent Psychiatry\, Neuroscience & Physiology and (Adult) Psychiatry
  and a Research Scientist VII in New York State\, Office of Mental Health.
   \n \n\nTo learn more about the Cognitive Neuroscience of Development and
  Aging (CoNDA) Center [P20GM130447]\, click here. For more information\, c
 ontact Kendall Panas (kpanas@unmc.edu).
LOCATION:
SUMMARY:CoNDA Center Seminar with Dr. Helen Scharfman (NYU)
URL;VALUE=URI:https://events.unmc.edu/event/conda-center-seminar-with-dr-he
 len-scharfman-nyu
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