Musculoskeletal Regeneration Research
Eben Alsberg, Ph.D. - Professor, Biomedical Engineering and Orthopaedic Surgery, Case Western Reserve University
The Alsberg laboratory focuses on engineering functional biologic replacements to repair damaged or diseased tissues in the body. They use the complex signals that are implicated in tissue morphogenesis, repair, and homeostasis as a template for the development of innovative biomaterials for tissue regeneration. Through the precise temporal and spatial presentation of soluble bioactive factors, mechanical forces, and biomaterial physical and biochemical properties, they aspire to create microenvironments that regulate cell gene expression and new tissue formation. Some areas of active investigation include controlling stem cell differentiation, delivering bioactive factors sequentially, developing spatially patterned constructs, understanding cell-cell interactions, and determining mechanical influences on cell function.
Treena Arinzeh – Professor, Biomedical Engineering, Newark College of Engineering
Treena Livingston Arinzeh, PhD, professor of biomedical engineering at NJIT, has earned national recognition for her commitment to making adult stem cell therapy a future reality. Her research interests include applied biomaterials and tissue engineering; cell-biomaterial interaction; materials processing; surface characterization and modification of biomaterials; materials testing; in vivo models; tissue-engineering scaffolds for repair of bone and other related musculoskeletal tissues; and nerve tissue regeneration utilizing stem cells.
Corey Neu - Associate Professor, Mechanical Engineering, University of Colorado Boulder
The Soft Tissue Bioengineering Laboratory run by Dr. Neu at CU Boulder is dedicated to technology development for fundamental study and engineering of connective and cardiac tissues. They desire to provide new therapies that emerge from a careful study of basic mechanobiology, to ultimately treat the millions of people worldwide afflicted with disorders of the connective and cardiac tissues, including arthritis and fibrosis, and to promote basic quality of life in humans. Their objectives are to create new scalable and integrated imaging tools to noninvasively probe dynamic functions in tissues and cells, understand the fundamental roles of physical factors in the growth, development, and maintenance of tissues, and develop novel strategies for the repair and regeneration of tissue structure and function. Mechanics is a central theme of the lab, with our basic science focus on mechanisms of physical force regulation, systems of stress and strain transfer over hierarchical scales, relationships between force and gene expression, inverse problems, and tissue stiffness, energy storage, and tribology. His lab routinely engages in interdisciplinary activities to solve complex interface problems, spanning multiple engineering and biology disciplines, including mechanical, electrical, micro/nanotechological, biochemical, and physiological subspecialties.
Xinping Zhang – Associate Professor, Center for Musculoskeletal Research, University of Rochester Medical Center
Research in Zhang's laboratory focuses on skeletal repair and reconstruction, which integrates a number of important research topics in musculoskeletal research. These topics include biology of bone/cartilage development, cell signaling, stem cell biology and bone tissue engineering. Using transgenic mouse models, primary culture of progenitor cells isolated from bone callus, and the-state-of-the-art imaging approaches, they are currently trying to understand how molecular and cellular signals are integrated to provide synergistic action for repair and regeneration. The long term goal of her laboratory is to be able to combine progenitor cells, molecular signals and bioscaffolds in a tissue-engineering construct to enhance bone repair and reconstruction.
10:00 - 10:30am - Introductory Remarks
10:30 - 11:30am - Speaker 1
11:30 - 11:45am - Break
11:45 - 12:45pm - Speaker 2
12:45 - 1:45pm - Lunch
1:45 - 2:45pm - Speaker 3
2:45 - 3:00pm - Break
3:00 - 4:00pm - Speaker 4
4:00 - 4:15pm - Break
4:15 - 5:15pm - Speaker 5
6:00pm - Dinner
Monday, September 18
University of Nebraska Medical Center, ESH 3010