How do plants activate defenses without running amok? Lessons from “aggie” to “bak to life” screens

Part of the UNL Biotechnology / Life Sciences seminar series. Visit their website for more information.

"How do plants activate defenses without running amok? Lessons from “aggie” to “bak to life” screens"

Presented by:
Dr. Ping He
Texas A & M University

Wednesday, September 6, 2017
4:00 p.m. Seminar, 3:30 p.m. Refreshments

University of Nebraska - Lincoln Campus
E103 Beadle Center

Lacking specialized immune cells, plants have evolved a multilayered innate immune system to fend off pathogen
threats. To understand how plants establish effective immunity yet without running amok, our lab has designed various sensitive and high throughput genetic screens in the reference plant Arabidopsis. A screen to understand defense activation with Arabidopsis expressing a luciferase reporter gene under the control of an immune responsive gene identified a series of Arabidopsis Genes Governing Immune gene Expression (AGGIE). The uncontrolled defense is oft endetrimental to the hosts, and potentially leads to massive cell death. The depletion of a key immune regulator BAK1 in Arabidopsis leads to spontaneous cell death with extensive defense activation. A RNA interference (RNAi)-based genetic screen for suppressors of BAK1-mediated cell death identified several "bak to life" (btl) mutants. The molecular and biochemical mechanisms underlying AGGIE-mediated plant defense regulation and BTL-mediated cell death control will be presented in the seminar.

Wednesday, September 6, 2017 at 3:30pm to 5:00pm

Beadle Center - UNL Campus, Room E103 1901 Vine Street, Lincoln, 68588

Event Type



Students, Faculty and Staff


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