This multidisciplinary symposium focuses on advances in hereditary cancer risk assessment, genetic evaluation, and precision cancer prevention. Sessions address inherited cancer syndromes across solid and hematologic malignancies, including Lynch syndrome, Li-Fraumeni syndrome, hereditary hematologic cancers, and practical guidance on screening, imaging, and genetic testing considerations. This hybrid conference, offered live and via Zoom, is an accredited continuing education activity designed for primary care and internal medicine providers, advanced practice providers, genetic counselors, nurses, scientists, and cancer research team members, and offers AMA, ANCC, and NSGC continuing education credit.